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Treating Corticobasal Syndrome (CBS)

The story of Don Sladek's journey with CBS


Vietnam Era Veteran Don and his wife, Chavonne Sladek

I’m Chavonne Sladek, and I’m Don Sladek’s wife. Don is a Vietnam Era veteran stationed in Southeast Asia and proudly served his country. We are not scientists or doctors; we are just regular people dealing with a terminal neurodegenerative disease called Corticobasal Syndrome (CBS). We are usually a private couple, but we are now compelled to share our unique story. It involves overcoming obstacles that affect all patients who have to go through the pharmaceutical industry to try and save their lives.

What is Corticobasal Syndrome?

Brain Icon

Corticobasal Syndrome (CBS) is the clinical diagnosis of Corticobasal Degeneration (CBD), which is finalized at autopsy. CBS has no known cause, treatment, or cure; and is a rare brain disease.  It is also a four-repeat tauopathy (4R-tau).  It affects nerve cells that control walking, balance, mobility, vision, speech, and swallowing. It is terminal, and the life expectancy is 6-8 years. Don is in year nine, and time is of the essence.

Why is this Situation Significant?

Vietnam Era Veteran Don Sladek receiving his infusion

The Treating Corticobasal Syndrome website was created after Don Sladek courageously and successfully participated in a Phase I trial with Biogen’s medication: BIIB092, Gosuranemab.  Don, with the help of his neurologist, Dr. Yvette Borderlon from the University of California, Los Angeles, was given single patient access.  Biogen is no longer manufacturing the drug. Don's last infusion was  June of 2023.  We believe with the passage of the Veteran's PACT-Act this medication could benefit other veterans and warrants further study.

What is the PACT Act?

Vietnam Era Veteran Don Sladek stationed in Udorn, Thailand in 1975

In August 2022, Congress, with a large bipartisan majority, passed, and the President signed the PACT-Act, a new law that expands VA health care and benefits to veterans exposed to toxic substances. Don served in the United States Air Force and was stationed at the Royal Thai Air Force Base in Udorn, Thailand, during 1974-75.  One of the sections of the Act, Title V, provides funding for research.  We believe Gosuranemab, as an important component of a care plan for Parkinsonsims has demonstrated some success and could help other veterans suffering from related neurodegenerative diseases.

How to Help

Vietnam Era Veteran Don Sladek in his dress uniform on leave in Rosamond, California in 1975

We believe the Passage of the PACT-Act demands research and treatment for our Veterans.  Currently, there are no treatment options for Corticobasal Syndrome patients and very few for those suffering from Chronic Traumatic Encephalopathy (CTE) and other neurodegenerative disorders.  We believe Biogen's Gosuranemab offers the best option for our Veterans.  The Veterans Administration Health Department needs to work in conjunction with Biogen to coordinate the manufacture, clinical trials, and treatment with Gosuranemab as part of a comprehensive care plan.


Please click the button below to view all the ways to help. 

Our Story

Chavonne Sladek's hand reaching out to Veteran Don Sladek's hand

Photo created by Gracie Sladek, Don's granddaughter

Video Evidence

Veteran Don Sladek smiling


Veteran Don Sladek is standing in front of his Christmas tree with blue lights and holding a blue ornament with the words, "Biogen."  His granddaughter, Gracie Sladek is to the left, and to the right is his wife, Chavonne Sladek.

There are not enough words to express our gratitude to Biogen.  We realize Gosuranemab is not a cure, but it has greatly improved Don's quality of life.  There is no other medication that has been shown to reverse and improve any neurodegenerative disease, but this drug has shown to be efficacious when supported with Dr. Yvette Bordelon's overall plan of care for Don and has been indispensable to his quality of life.  We would like to thank all of Biogen for caring deeply and working fearlessly.

Don's appreciation to Biogen after two years of Single Patient Expanded Use

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